Baby Safety / Compounds / Vinclozolin

Is Vinclozolin safe for babies and kids?

Very high risk for kids

Infants are susceptible to Vinclozolin through dietary residues on produce. Developing endocrine and hepatic systems increase vulnerability to antifungal compounds.

What is vinclozolin?

The IUPAC name is 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-1,3-oxazolidine-2,4-dione.

Also known as: Ronilan, Vinclozoline, Ornalin, Vorlan.

IUPAC name
3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-1,3-oxazolidine-2,4-dione
CAS number
50471-44-8
Molecular formula
C12H9Cl2NO3
Molecular weight
286.11 g/mol
SMILES
CC1(OC(=O)N(C1=O)c1cc(Cl)cc(Cl)c1)C=C
PubChem CID
39676

Risk for babies

Very high risk

Infants are susceptible to Vinclozolin through dietary residues on produce. Developing endocrine and hepatic systems increase vulnerability to antifungal compounds.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

High risk

Prenatal exposure to Vinclozolin may affect fetal development through endocrine disruption pathways. Several fungicide classes (azoles, dicarboximides) interfere with steroid biosynthesis.

Known reproductive toxicant (GHS H360) or confirmed endocrine disruptor. Placental transfer is presumed. Fetal exposure during critical developmental windows may cause structural malformations, growth restriction, or functional deficits.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

3 regulatory and scientific bodies have classified Vinclozolin. The classifications differ — that's the data.

AgencyYearClassificationNotes
EU2006Banned — endocrine disruptor (Reg 2006/1015/EC)
EPA2010Registrations voluntarily cancelled
TEDX2015Listed endocrine disruptor

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter vinclozolin

  • Agricultural

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Vinclozolin:

  • Fludioxonil (non-endocrine-active fungicide)
    Trade-offs: Alternative fungicide or disease management strategy; spectrum of activity differs from original compound; resistance management considerations apply; integrated pest management approach recommended.
    Relative cost: 1.2-2×
  • Boscalid (SDHI fungicide)
    Trade-offs: Alternative fungicide or disease management strategy; spectrum of activity differs from original compound; resistance management considerations apply; integrated pest management approach recommended.
    Relative cost: 1.2-2×

Frequently asked questions

Is vinclozolin safe for kids?

Infants are susceptible to Vinclozolin through dietary residues on produce. Developing endocrine and hepatic systems increase vulnerability to antifungal compounds.

What should I do if my child is exposed to vinclozolin?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Why do regulators disagree about vinclozolin?

Vinclozolin has been classified by 3 agencies including EU, EPA, TEDX, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See Vinclozolin in the baby app

Look up products containing vinclozolin, compare to alternatives, and explore the full data record.

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Sources (1)
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Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →