Baby Safety / Compounds / Trimethylpyrazine

Is Trimethylpyrazine safe for babies and kids?

Context-dependent for kids

(Babies-specific data is limited; this page draws from human pregnant context.) Pregnancy alters the metabolism and distribution of Trimethylpyrazine, potentially increasing fetal exposure. The developing embryo/fetus is vulnerable during organogenesis (weeks 3-8) and neurological development. Placental transfer should be assumed.

What is trimethylpyrazine?

The IUPAC name is 2,5,6-trimethylpyrazine.

Also known as: 2,5,6-trimethylpyrazine, 2,3,5-Trimethylpyrazine, Pyrazine, trimethyl-, 2,3,5-Trimethyl pyrazine.

IUPAC name
2,5,6-trimethylpyrazine
CAS number
14667-55-1
Molecular formula
C7H10N2
Molecular weight
122.17 g/mol
SMILES
CC1=CN=C(C(=N1)C)C
PubChem CID
26808

Risk for babies

Context-dependent

Pregnancy alters the metabolism and distribution of Trimethylpyrazine, potentially increasing fetal exposure. The developing embryo/fetus is vulnerable during organogenesis (weeks 3-8) and neurological development. Placental transfer should be assumed.

No specific reproductive toxicity data identified, but pregnancy-specific safety data is limited for most chemicals. Precautionary minimization of exposure is recommended.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Risk for pregnant and nursing people

Context-dependent

Pregnancy alters the metabolism and distribution of Trimethylpyrazine, potentially increasing fetal exposure. The developing embryo/fetus is vulnerable during organogenesis (weeks 3-8) and neurological development. Placental transfer should be assumed.

No specific reproductive toxicity data identified, but pregnancy-specific safety data is limited for most chemicals. Precautionary minimization of exposure is recommended.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

2 regulatory and scientific bodies have classified Trimethylpyrazine. The classifications differ — that's the data.

AgencyYearClassificationNotes
FDA——
EFSA——

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter trimethylpyrazine

  • coffee flavoring
  • roasted flavoring
  • chocolate flavoring

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Trimethylpyrazine:

  • Natural cocoa extract (contains trimethylpyrazine)
    Trade-offs: Complex mixture — harder to control specific flavor note. Contains theobromine.
    Relative cost: 2-3×

Frequently asked questions

What products contain trimethylpyrazine?

Trimethylpyrazine appears in: coffee flavoring; roasted flavoring; chocolate flavoring.

See Trimethylpyrazine in the baby app

Look up products containing trimethylpyrazine, compare to alternatives, and explore the full data record.

Open in baby View raw API data

Sources (1)
  1. ATSDR Toxicological Profile — CAS 14667-55-1 — reference

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →