Baby Safety / Compounds / Oleamide

Is Oleamide safe for babies and kids?

High risk for kids

Infants are more vulnerable to Oleamide than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

What is oleamide?

The IUPAC name is 9-octadecenamide.

Also known as: 9-octadecenamide, Oleic acid amide, Slip agent, p-Anisidine.

IUPAC name
9-octadecenamide
CAS number
301-02-0
Molecular formula
C18H35NO
Molecular weight
281.48 g/mol
SMILES
COC1=CC=C(C=C1)N
PubChem CID
7732

Risk for babies

High risk

Infants are more vulnerable to Oleamide than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

Context-dependent

Pregnancy alters the metabolism and distribution of Oleamide, potentially increasing fetal exposure. The developing embryo/fetus is vulnerable during organogenesis (weeks 3-8) and neurological development. Placental transfer should be assumed.

No specific reproductive toxicity data identified, but pregnancy-specific safety data is limited for most chemicals. Precautionary minimization of exposure is recommended.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

2 regulatory and scientific bodies have classified Oleamide. The classifications differ — that's the data.

AgencyYearClassificationNotes
REACH——No SVHC; no restrictions despite CNS activity data
FDA——Permitted in food contact applications; CFR Part 178 compliant

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter oleamide

  • polyethylene
  • polypropylene
  • polyolefins
  • film_materials
  • plastic_sheets

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Oleamide:

  • Bio-based plasticizers (epoxidized soybean oil, citrate esters)
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 2-5× conventional
  • Non-phthalate plasticizers (DINCH, DEHT) where phthalates are currently used
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×
  • Additive-free polymer formulations where performance allows
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: Lower (ingredient elimination)

Frequently asked questions

Is oleamide safe for kids?

Infants are more vulnerable to Oleamide than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

What products contain oleamide?

Oleamide appears in: polyethylene; polypropylene; polyolefins.

What should I do if my child is exposed to oleamide?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See Oleamide in the baby app

Look up products containing oleamide, compare to alternatives, and explore the full data record.

Open in baby View raw API data

Sources (2)
  1. PubChem Compound CID 7732 — database
  2. ATSDR Toxicological Profile — CAS 301-02-0 — reference

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →