Baby Safety / Compounds / Lisinopril

Is Lisinopril safe for babies and kids?

Moderate risk for kids

Infants have immature drug-metabolizing enzymes (CYP450 ontogeny), reduced renal clearance, and different volume of distribution. Accidental exposure or breast milk transfer of Lisinopril poses heightened risk.

What is lisinopril?

The IUPAC name is (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate.

Also known as: (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate, Lisinopril dihydrate, DTXCID0025600, LISINOPRIL DIHYDRATE [MI].

IUPAC name
(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate
CAS number
83915-83-7
Molecular formula
C21H35N3O7
Molecular weight
441.5 g/mol
SMILES
C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
PubChem CID
5362118

Risk for babies

Moderate risk

Infants have immature drug-metabolizing enzymes (CYP450 ontogeny), reduced renal clearance, and different volume of distribution. Accidental exposure or breast milk transfer of Lisinopril poses heightened risk.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

Elevated risk

Lisinopril poses pregnancy risk through potential teratogenicity, altered pharmacokinetics (increased blood volume, changed CYP activity), and placental transfer. FDA pregnancy category should be evaluated.

Suspected reproductive toxicant (GHS H361) or suspected endocrine disruptor. Precautionary approach warranted. Animal studies or limited human data suggest developmental toxicity potential.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

2 regulatory and scientific bodies have classified Lisinopril. The classifications differ — that's the data.

AgencyYearClassificationNotes
FDA—Black Box WarningAngioedema - rare but potentially life-threatening; non-allergic angioedema of face, lips, tongue, throat, or larynx; can cause airway obstruction
FDA—Black Box WarningTeratogenicity - ACE inhibitors contraindicated in pregnancy; Category D in 2nd/3rd trimester due to fetal renal tubular dysplasia, oligohydramnios, limb contractures, neonatal skull hypoplasia, renal failure, death

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter lisinopril

  • Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
  • Occupational Environments — Factories, Warehouses, Transportation vehicles

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Lisinopril:

  • Alternative drug class; Non-pharmacological therapy; Lowest effective dose
    Trade-offs: Direct chemical substitution requires verification that the replacement does not introduce new hazards (regrettable substitution). Conduct full hazard assessment of proposed alternative before adoption.
    Relative cost: 1.2-2×

Frequently asked questions

Is lisinopril safe for kids?

Infants have immature drug-metabolizing enzymes (CYP450 ontogeny), reduced renal clearance, and different volume of distribution. Accidental exposure or breast milk transfer of Lisinopril poses heightened risk.

What products contain lisinopril?

Lisinopril appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).

What should I do if my child is exposed to lisinopril?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See Lisinopril in the baby app

Look up products containing lisinopril, compare to alternatives, and explore the full data record.

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Sources (2)
  1. FDA Prescribing Information: Lisinopril (Prinivil/Zestril) — ACE inhibitor; Black Box angioedema + pregnancy; cough; renal artery stenosis; hyperkalemia; pediatric hypertension ≥6yr; CKD proteinuria; Black Americans risk; WHO Essential Medicine (2023) (2023) — regulatory
  2. ASPCA Animal Poison Control Center: Cardiac Drug Toxicosis in Pets — statin myopathy in cats; beta-blocker bradycardia dogs; CCB toxicity (amlodipine/diltiazem); ACE inhibitor renal effects; warfarin anticoagulant; furosemide; toxic dose thresholds (2023) (2023) — veterinary

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →