Baby Safety / Compounds / Iso E Super (OTNE)

Is Iso E Super (OTNE) safe for babies and kids?

Moderate risk for kids

Infants are more vulnerable to Iso E Super (OTNE) than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

What is iso e super (otne)?

The IUPAC name is 1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone.

Also known as: 1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone, OHTMNE cpd, RefChem:791818.

IUPAC name
1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone
CAS number
54464-57-2
Molecular formula
C16H26O
Molecular weight
234.38 g/mol
SMILES
CC1CC2=C(CC1(C)C(=O)C)C(CCC2)(C)C
PubChem CID
108242

Risk for babies

Moderate risk

Infants are more vulnerable to Iso E Super (OTNE) than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

Context-dependent

Prenatal exposure to Iso E Super (OTNE) through personal care products may affect fetal development. Some fragrance chemicals are sensitizers or endocrine-active compounds with transplacental transfer.

No specific reproductive toxicity data identified, but pregnancy-specific safety data is limited for most chemicals. Precautionary minimization of exposure is recommended.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

2 regulatory and scientific bodies have classified Iso E Super (OTNE). The classifications differ — that's the data.

AgencyYearClassificationNotes
IFRA2020restrictionIFRA restriction
EU_REACH2017CoRAPCoRAP evaluation — persistence

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter iso e super (otne)

  • Personal Care — perfume, cologne, deodorant, soap, shampoo
  • Consumer Products — detergent, air freshener
  • Fragrance — perfume, cologne, scented personal care products, household fragrance products, candles
    Identified in Fragrance Ingredient Safety Priority Research database (2,325 ingredients)

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Iso E Super (OTNE):

  • Javanol
    Trade-offs: Alternative fragrance ingredient; individual safety profile should be assessed per IFRA standards; sensitization potential varies by compound; patch testing recommended for sensitive individuals.
    Relative cost: 1.2-2×
  • Cashmeran
    Trade-offs: Alternative fragrance ingredient; individual safety profile should be assessed per IFRA standards; sensitization potential varies by compound; patch testing recommended for sensitive individuals.
    Relative cost: 1.2-2×
  • Ambroxan
    Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
    Relative cost: 1.2-2×
  • Georgywood
    Trade-offs: Alternative fragrance ingredient; individual safety profile should be assessed per IFRA standards; sensitization potential varies by compound; patch testing recommended for sensitive individuals.
    Relative cost: 1.2-2×

Frequently asked questions

Is iso e super (otne) safe for kids?

Infants are more vulnerable to Iso E Super (OTNE) than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

What products contain iso e super (otne)?

Iso E Super (OTNE) appears in: perfume (Personal care); cologne (Personal care); detergent (Consumer products); air freshener (Consumer products); perfume (Fragrance).

What should I do if my child is exposed to iso e super (otne)?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See Iso E Super (OTNE) in the baby app

Look up products containing iso e super (otne), compare to alternatives, and explore the full data record.

Open in baby View raw API data

Sources (1)
  1. PubChem Compound Database (2026) — database

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →