Baby Safety / Compounds / Irganox 1010

Is Irganox 1010 safe for babies and kids?

High risk for kids

Infants are more vulnerable to Irganox 1010 than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

What is irganox 1010?

The IUPAC name is pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate).

Also known as: pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate), Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate), PEPT.

IUPAC name
pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)
CAS number
6683-19-8
Molecular formula
C73H108O12
Molecular weight
1177.67 g/mol
SMILES
CC(C=O)OC1C(C2OCC(C1OC3C(C(C(C(O3)CO)O)O)NC(=O)C)O2)NC(=O)C
PubChem CID
6323430

Risk for babies

High risk

Infants are more vulnerable to Irganox 1010 than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

Context-dependent

Pregnancy alters the metabolism and distribution of Irganox 1010, potentially increasing fetal exposure. The developing embryo/fetus is vulnerable during organogenesis (weeks 3-8) and neurological development. Placental transfer should be assumed.

No specific reproductive toxicity data identified, but pregnancy-specific safety data is limited for most chemicals. Precautionary minimization of exposure is recommended.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

2 regulatory and scientific bodies have classified Irganox 1010. The classifications differ — that's the data.

AgencyYearClassificationNotes
REACH——No SVHC; no restrictions; widely accepted
FDA——Permitted in food packaging; CFR Part 178 compliant

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter irganox 1010

  • polyethylene
  • polypropylene
  • polyolefins
  • food_packaging
  • plastic_films

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Irganox 1010:

  • Bio-based plasticizers (epoxidized soybean oil, citrate esters)
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 2-5× conventional
  • Non-phthalate plasticizers (DINCH, DEHT) where phthalates are currently used
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: 1.2-2×
  • Additive-free polymer formulations where performance allows
    Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
    Relative cost: Lower (ingredient elimination)

Frequently asked questions

Is irganox 1010 safe for kids?

Infants are more vulnerable to Irganox 1010 than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

What products contain irganox 1010?

Irganox 1010 appears in: polyethylene; polypropylene; polyolefins.

What should I do if my child is exposed to irganox 1010?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See Irganox 1010 in the baby app

Look up products containing irganox 1010, compare to alternatives, and explore the full data record.

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Sources (2)
  1. PubChem Compound CID 6323430 — database
  2. ATSDR Toxicological Profile — CAS 6683-19-8 — reference

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →