Baby Safety / Compounds / Flupyradifurone

Is Flupyradifurone safe for babies and kids?

Moderate risk for kids

Infants are acutely vulnerable to Flupyradifurone due to immature acetylcholinesterase regulation, higher dermal absorption per unit body weight, and frequent floor-level exposure to residues.

What is flupyradifurone?

The IUPAC name is 3-[(6-chloro-3-pyridinyl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one.

Also known as: 3-[(6-chloro-3-pyridinyl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one, 4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan-2(5H)-one, 8H7JT159D0, BYI-02960.

IUPAC name
3-[(6-chloro-3-pyridinyl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one
CAS number
951659-40-8
Molecular formula
C12H11ClF2N2O2
Molecular weight
288.68 g/mol
SMILES
C1C(=CC(=O)O1)N(CC2=CN=C(C=C2)Cl)CC(F)F
PubChem CID
16752772

Risk for babies

Moderate risk

Infants are acutely vulnerable to Flupyradifurone due to immature acetylcholinesterase regulation, higher dermal absorption per unit body weight, and frequent floor-level exposure to residues.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

Elevated risk

Prenatal exposure to Flupyradifurone is associated with neurodevelopmental effects. Organophosphate/carbamate insecticides inhibit acetylcholinesterase, which plays a role in fetal brain development.

Suspected reproductive toxicant (GHS H361) or suspected endocrine disruptor. Precautionary approach warranted. Animal studies or limited human data suggest developmental toxicity potential.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

1 regulatory bodyhas classified Flupyradifurone.

AgencyYearClassificationNotes
US EPA2015Toxicity Category IVEPA registration with specific restrictions to protect pollinators

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter flupyradifurone

  • Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
  • Occupational Environments — Factories, Warehouses, Transportation vehicles

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Flupyradifurone:

  • Physical/mechanical pest control (IPM)
    Trade-offs: More labor-intensive. May not be sufficient for severe infestations.
    Relative cost: 1.2-2×

Frequently asked questions

Is flupyradifurone safe for kids?

Infants are acutely vulnerable to Flupyradifurone due to immature acetylcholinesterase regulation, higher dermal absorption per unit body weight, and frequent floor-level exposure to residues.

What products contain flupyradifurone?

Flupyradifurone appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).

What should I do if my child is exposed to flupyradifurone?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See Flupyradifurone in the baby app

Look up products containing flupyradifurone, compare to alternatives, and explore the full data record.

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Sources (2)
  1. EFSA: Flupyradifurone Peer Review — bee risk assessment; synergism with EBI fungicides; acute and sublethal bee toxicity; comparison with neonicotinoid outdoor ban criteria; review of 'bee-safe' claims; EFSA Scientific Opinion (2020) (2020) — regulatory
  2. US EPA: Neonicotinoid Registration Review — imidacloprid, clothianidin, thiamethoxam, acetamiprid, dinotefuran; bee risk assessment; sublethal effects; colony-level modeling; pollinator exposure through pollen and nectar; aquatic invertebrate toxicity; registration review decision (2020) (2020) — regulatory

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →