Baby Safety / Compounds / diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2)

Is diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) safe for babies and kids?

Very high risk for kids

Infants accumulate diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) through breast milk (bioconcentration), placental transfer, and dust ingestion. Persistent pollutants concentrate in fatty tissues with extended half-lives in developing organisms.

What is dipap (polyfluoroalkyl phosphate diester, 6:2/6:2)?

The IUPAC name is bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen phosphate.

Also known as: Bis[2-(perfluorohexyl)ethyl] Phosphate, bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen phosphate, Bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octanol) hydrogen phosphate, DTXSID50561590.

IUPAC name
bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen phosphate
CAS number
57677-95-9
Molecular formula
C16H9F26O4P
Molecular weight
790.17 g/mol
SMILES
C(COP(=O)(O)OCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F
PubChem CID
14550408

Risk for babies

Very high risk

Infants accumulate diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) through breast milk (bioconcentration), placental transfer, and dust ingestion. Persistent pollutants concentrate in fatty tissues with extended half-lives in developing organisms.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

High risk

diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) persists in maternal adipose tissue and is mobilized during pregnancy and lactation. Lipophilic pollutants concentrate in breast milk and cross the placenta during critical developmental windows.

Suspected reproductive toxicant (GHS H361) or suspected endocrine disruptor. Precautionary approach warranted. Animal studies or limited human data suggest developmental toxicity potential.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

3 regulatory and scientific bodies have classified diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2). The classifications differ — that's the data.

AgencyYearClassificationNotes
FDA——FDA revoked authorization for certain PFAS in food packaging in 2024
ECHA——
Denmark——Denmark banned PFAS in food packaging in 2020

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter dipap (polyfluoroalkyl phosphate diester, 6:2/6:2)

  • Food Packaging — Fast food wrappers, Microwave popcorn bags, Pizza boxes, Bakery bags
    Dominant PFAS in food-contact paper — detected in >50% of fast food packaging
  • House Dust — Household dust, Office dust
    Dust from treated textiles and carpets contains diPAPs
  • Human Biomonitoring — General population serum, Fast food workers
    Detected in human blood — dietary exposure from food packaging is primary route

Safer alternatives

Lower-risk approaches that achieve a similar outcome to diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2):

  • Plant-based grease barriers
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Wax-coated paper
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Bamboo fiber packaging
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×
  • Silicone-coated paper
    Trade-offs: Functional performance and cost-effectiveness may vary by application.
    Relative cost: 1.2-2×

Frequently asked questions

Is dipap (polyfluoroalkyl phosphate diester, 6:2/6:2) safe for kids?

Infants accumulate diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) through breast milk (bioconcentration), placental transfer, and dust ingestion. Persistent pollutants concentrate in fatty tissues with extended half-lives in developing organisms.

What products contain dipap (polyfluoroalkyl phosphate diester, 6:2/6:2)?

diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) appears in: Fast food wrappers (food packaging); Microwave popcorn bags (food packaging); Household dust (house dust); Office dust (house dust); General population serum (human biomonitoring).

What should I do if my child is exposed to dipap (polyfluoroalkyl phosphate diester, 6:2/6:2)?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See diPAP (Polyfluoroalkyl phosphate diester, 6:2/6:2) in the baby app

Look up products containing dipap (polyfluoroalkyl phosphate diester, 6:2/6:2), compare to alternatives, and explore the full data record.

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Sources (1)
  1. — expert_curation

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →