Baby Safety / Compounds / D6 dodecamethylcyclohexasiloxane

Is D6 dodecamethylcyclohexasiloxane safe for babies and kids?

Context-dependent for kids

Infants are more vulnerable to D6 dodecamethylcyclohexasiloxane than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

What is d6 dodecamethylcyclohexasiloxane?

Also known as: DODECAMETHYLCYCLOHEXASILOXANE, Cyclohexasiloxane, dodecamethyl-, Cyclomethicone 6, XHK3U310BA.

CAS number
540-97-6
Molecular formula
C12H36O6Si6
Molecular weight
444.92 g/mol
SMILES
C[Si]1(O[Si](O[Si](O[Si](O[Si](O[Si](O1)(C)C)(C)C)(C)C)(C)C)(C)C)C
PubChem CID
10911

Risk for babies

Context-dependent

Infants are more vulnerable to D6 dodecamethylcyclohexasiloxane than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

Context-dependent

Regulatory consensus

1 regulatory bodyhas classified D6 dodecamethylcyclohexasiloxane.

AgencyYearClassificationNotes
EDC Assessment—Suspected endocrine disruptor

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter d6 dodecamethylcyclohexasiloxane

  • Consumer Products — various

Safer alternatives

Lower-risk approaches that achieve a similar outcome to D6 dodecamethylcyclohexasiloxane:

  • Linear siloxanes; Non-silicone alternatives
    Trade-offs: Direct chemical substitution requires verification that the replacement does not introduce new hazards (regrettable substitution). Conduct full hazard assessment of proposed alternative before adoption.
    Relative cost: 1.2-2×

Frequently asked questions

Is d6 dodecamethylcyclohexasiloxane safe for kids?

Infants are more vulnerable to D6 dodecamethylcyclohexasiloxane than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.

What products contain d6 dodecamethylcyclohexasiloxane?

D6 dodecamethylcyclohexasiloxane appears in: various (Consumer products).

What should I do if my child is exposed to d6 dodecamethylcyclohexasiloxane?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See D6 dodecamethylcyclohexasiloxane in the baby app

Look up products containing d6 dodecamethylcyclohexasiloxane, compare to alternatives, and explore the full data record.

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Sources (1)
  1. PubChem (2026) — database

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →