Baby Safety / Compounds / cis-3-Hexenyl salicylate

Is cis-3-Hexenyl salicylate safe for babies and kids?

Low risk for kids

(Babies-specific data is limited; this page draws from human adult context.) cis-3-Hexenyl salicylate poses low risk to adults under normal use conditions.

What is cis-3-hexenyl salicylate?

Also known as: 3-Hexenyl salicylate, C78Y9OR6YH, 2-Hydroxybenzoic acid, (Z)-3-hexenyl ester, FEMA NO. 4750.

CAS number
65405-77-8
Molecular formula
C13H16O3
Molecular weight
220.26 g/mol
SMILES
CCC=CCCOC(=O)C1=CC=CC=C1O
PubChem CID
6021887

Risk for babies

Low risk

cis-3-Hexenyl salicylate poses low risk to adults under normal use conditions.

Regulatory consensus

2 regulatory and scientific bodies have classified cis-3-Hexenyl salicylate. The classifications differ — that's the data.

AgencyYearClassificationNotes
IFRA——Approved for use in fragrance compounds
EU——Complies with EU cosmetics regulations

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter cis-3-hexenyl salicylate

  • Perfume
  • Personal Care

Safer alternatives

Lower-risk approaches that achieve a similar outcome to cis-3-Hexenyl salicylate:

  • Essential oil-free fragrance formulations
    Trade-offs: Allows scent without specific natural allergens; synthetic molecules can be individually safety-tested; some synthetics have their own sensitization profiles; cost comparable to natural blends.
    Relative cost: Lower (ingredient elimination)
  • Naturally-derived isolates with established safety profiles (e.g., linalool, limonene at controlled concentrations)
    Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
    Relative cost: 2-5× conventional
  • Fragrance-free product alternatives
    Trade-offs: Eliminates allergen risk entirely; consumer acceptance varies (some associate scent with cleanliness/efficacy); growing market segment; regulatory advantage in EU (no IFRA compliance needed).
    Relative cost: Lower (ingredient elimination)
  • Encapsulated fragrance technologies (reduced skin contact)
    Trade-offs: Reduces dermal contact by 60-90% via polymer shell release mechanism; higher formulation cost; may alter scent perception (delayed release); shell material itself requires safety assessment.
    Relative cost: 1.2-2×

Frequently asked questions

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Sources (1)
  1. ATSDR Toxicological Profile — CAS 65405-77-8 — reference

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →