Is cis-1,4-Polyisoprene safe for babies and kids?
Severe risk for kidsInfants may be exposed to cis-1,4-Polyisoprene through residual monomer migration from food-contact plastics, bottles, and packaging. Immature hepatic conjugation and renal clearance prolong internal exposure.
What is cis-1,4-polyisoprene?
The IUPAC name is 2-methylbuta-1,3-diene.
Also known as: 2-methylbuta-1,3-diene, ISOPRENE, 2-Methyl-1,3-butadiene, Isopentadiene.
- IUPAC name
- 2-methylbuta-1,3-diene
- CAS number
- 9006-04-6
- Molecular formula
- C5H8
- Molecular weight
- 68.12 g/mol
- SMILES
- CC(=C)C=C
- PubChem CID
- 6557
Risk for babies
Severe riskInfants may be exposed to cis-1,4-Polyisoprene through residual monomer migration from food-contact plastics, bottles, and packaging. Immature hepatic conjugation and renal clearance prolong internal exposure.
Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.
Risk for pregnant and nursing people
Context-dependentPrenatal exposure to residual cis-1,4-Polyisoprene from food-contact materials is a concern due to potential developmental toxicity. Monomers may leach from plastics at elevated temperatures.
No specific reproductive toxicity data identified, but pregnancy-specific safety data is limited for most chemicals. Precautionary minimization of exposure is recommended.
Regulatory consensus
2 regulatory and scientific bodies have classified cis-1,4-Polyisoprene. The classifications differ — that's the data.
| Agency | Year | Classification | Notes |
|---|---|---|---|
| EPA CTX / Genetox | — | Genotoxicity: positive (Ames: positive, 8 positive / 1 negative reports) | |
| EPA CTX / Genetox | — | Genotoxicity: positive (Ames: positive, 8 positive / 1 negative reports) |
Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.
Where kids encounter cis-1,4-polyisoprene
- Industrial Facilities — Manufacturing plants, Waste treatment sites
- Occupational Environments — Factories, Warehouses
Safer alternatives
Lower-risk approaches that achieve a similar outcome to cis-1,4-Polyisoprene:
-
Calcium carbonate or kaolin fillers
Trade-offs: Different performance characteristics than specialty fillers.Relative cost: 1.2-2×
Frequently asked questions
Is cis-1,4-polyisoprene safe for kids?
Infants may be exposed to cis-1,4-Polyisoprene through residual monomer migration from food-contact plastics, bottles, and packaging. Immature hepatic conjugation and renal clearance prolong internal exposure.
What products contain cis-1,4-polyisoprene?
cis-1,4-Polyisoprene appears in: Manufacturing plants (Industrial facilities); Waste treatment sites (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).
What should I do if my child is exposed to cis-1,4-polyisoprene?
Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.
See cis-1,4-Polyisoprene in the baby app
Look up products containing cis-1,4-polyisoprene, compare to alternatives, and explore the full data record.
Open in baby View raw API dataSources (3)
- PubChem Compound CID 6557 — database
- EPA CompTox Chemicals Dashboard — DTXSID20107787 — epa
- ATSDR Toxicological Profile — CAS 9006-04-6 — reference
Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →