Baby Safety / Compounds / Chlorantraniliprole

Is Chlorantraniliprole safe for babies and kids?

Moderate risk for kids

Infants are acutely vulnerable to Chlorantraniliprole due to immature acetylcholinesterase regulation, higher dermal absorption per unit body weight, and frequent floor-level exposure to residues.

What is chlorantraniliprole?

The IUPAC name is 3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloro-2-pyridinyl)pyrazole-5-carboxamide.

Also known as: 3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloro-2-pyridinyl)pyrazole-5-carboxamide, DPX-E2Y45, chlorantranilipole, Rynaxpyr.

IUPAC name
3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloro-2-pyridinyl)pyrazole-5-carboxamide
CAS number
500008-45-7
Molecular formula
C18H14BrCl2N5O2
Molecular weight
483.1 g/mol
SMILES
CC1=CC(=CC(=C1NC(=O)C2=CC(=NN2C3=C(C=CC=N3)Cl)Br)C(=O)NC)Cl
PubChem CID
11271640

Risk for babies

Moderate risk

Infants are acutely vulnerable to Chlorantraniliprole due to immature acetylcholinesterase regulation, higher dermal absorption per unit body weight, and frequent floor-level exposure to residues.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

Elevated risk

Prenatal exposure to Chlorantraniliprole is associated with neurodevelopmental effects. Organophosphate/carbamate insecticides inhibit acetylcholinesterase, which plays a role in fetal brain development.

Suspected reproductive toxicant (GHS H361) or suspected endocrine disruptor. Precautionary approach warranted. Animal studies or limited human data suggest developmental toxicity potential.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

1 regulatory bodyhas classified Chlorantraniliprole.

AgencyYearClassificationNotes
US EPA (FIFRA pesticide registration)2020not likely to be carcinogenic to humans; registered as Rynaxypyr/Coragen/DuPont Altacor; anthranilic diamide insecticide with novel ryanodine receptor mechanism; not classified for carcinogenicity by IARC or EFSA

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter chlorantraniliprole

  • Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
  • Occupational Environments — Factories, Warehouses, Transportation vehicles

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Chlorantraniliprole:

  • Physical/mechanical pest control (IPM)
    Trade-offs: More labor-intensive. May not be sufficient for severe infestations.
    Relative cost: 1.2-2×

Frequently asked questions

Is chlorantraniliprole safe for kids?

Infants are acutely vulnerable to Chlorantraniliprole due to immature acetylcholinesterase regulation, higher dermal absorption per unit body weight, and frequent floor-level exposure to residues.

What products contain chlorantraniliprole?

Chlorantraniliprole appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).

What should I do if my child is exposed to chlorantraniliprole?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See Chlorantraniliprole in the baby app

Look up products containing chlorantraniliprole, compare to alternatives, and explore the full data record.

Open in baby View raw API data

Sources (2)
  1. US EPA FIFRA Chlorantraniliprole Rynaxypyr Coragen Registration 2008: Not Likely Carcinogenic; LD50 >5000 mg/kg; Ryanodine Receptor Insect 300x Selectivity; Not Reproductive Toxicant; Low Bee Contact Toxicity (2020) — regulatory
  2. EFSA Chlorantraniliprole Peer Review 2020: Not Carcinogenic Not Genotoxic; ADI 0.1 mg/kg bw/day; Low Mammalian RyR Sensitivity; Larval Bee Toxicity Concern Pollen; Moderate Sediment Invertebrate Risk (2020) — regulatory

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →