Baby Safety / Compounds / Antipyrine

Is Antipyrine safe for babies and kids?

High risk for kids

Infants have immature drug-metabolizing enzymes (CYP450 ontogeny), reduced renal clearance, and different volume of distribution. Accidental exposure or breast milk transfer of Antipyrine poses heightened risk.

What is antipyrine?

Also known as: Phenazone, Analgesine, Antipyrin, Fenazone.

CAS number
60-80-0
Molecular formula
C11H12N2O
Molecular weight
188.23 g/mol
SMILES
CC1=CC(=O)N(N1C)C2=CC=CC=C2
PubChem CID
2206

Risk for babies

High risk

Infants have immature drug-metabolizing enzymes (CYP450 ontogeny), reduced renal clearance, and different volume of distribution. Accidental exposure or breast milk transfer of Antipyrine poses heightened risk.

Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.

What to do: Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

Risk for pregnant and nursing people

Elevated risk

Antipyrine poses pregnancy risk through potential teratogenicity, altered pharmacokinetics (increased blood volume, changed CYP activity), and placental transfer. FDA pregnancy category should be evaluated.

Suspected reproductive toxicant (GHS H361) or suspected endocrine disruptor. Precautionary approach warranted. Animal studies or limited human data suggest developmental toxicity potential.

What to do: Minimize exposure during pregnancy and lactation. Consult healthcare provider regarding specific risks. Consider alternative products with lower hazard profiles.

Regulatory consensus

1 regulatory bodyhas classified Antipyrine.

AgencyYearClassificationNotes
Regulatory Framework—Regulated as pharmaceutical (FDA/EMA); not typically classified under industrial chemical regulations

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter antipyrine

  • Agricultural Products — crop treatment

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Antipyrine:

  • Alternative drug class; Lowest effective dose
    Trade-offs: Direct chemical substitution requires verification that the replacement does not introduce new hazards (regrettable substitution). Conduct full hazard assessment of proposed alternative before adoption.
    Relative cost: 1.2-2×

Frequently asked questions

Is antipyrine safe for kids?

Infants have immature drug-metabolizing enzymes (CYP450 ontogeny), reduced renal clearance, and different volume of distribution. Accidental exposure or breast milk transfer of Antipyrine poses heightened risk.

What products contain antipyrine?

Antipyrine appears in: crop treatment (Agricultural products).

What should I do if my child is exposed to antipyrine?

Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.

See Antipyrine in the baby app

Look up products containing antipyrine, compare to alternatives, and explore the full data record.

Open in baby View raw API data

Sources (1)
  1. PubChem (2026) — database

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →