Is AαC (2-Amino-9H-pyrido[2,3-b]indole) safe for babies and kids?
Moderate risk for kidsInfants are more vulnerable to AαC (2-Amino-9H-pyrido[2,3-b]indole) than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.
What is aαc (2-amino-9h-pyrido[2,3-b]indole)?
The IUPAC name is 9H-pyrido[2,3-b]indol-2-amine.
Also known as: 9H-pyrido[2,3-b]indol-2-amine, 2-Amino-9H-pyrido[2,3-b]indole, AalphaC, A-alpha-C.
- IUPAC name
- 9H-pyrido[2,3-b]indol-2-amine
- CAS number
- 26148-68-5
- Molecular formula
- C11H9N3
- Molecular weight
- 183.21 g/mol
- SMILES
- C1=CC=C2C(=C1)C3=C(N2)N=C(C=C3)N
- PubChem CID
- 62805
Risk for babies
Moderate riskInfants are more vulnerable to AαC (2-Amino-9H-pyrido[2,3-b]indole) than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.
Neonates and infants up to 12 months have incomplete blood-brain barrier development, immature Phase I/II metabolic enzymes (particularly CYP3A4, UGT1A1), and higher gastrointestinal permeability. Equivalent doses produce higher internal concentrations and longer residence times.
Risk for pregnant and nursing people
Context-dependentPregnancy alters the metabolism and distribution of AαC (2-Amino-9H-pyrido[2,3-b]indole), potentially increasing fetal exposure. The developing embryo/fetus is vulnerable during organogenesis (weeks 3-8) and neurological development. Placental transfer should be assumed.
No specific reproductive toxicity data identified, but pregnancy-specific safety data is limited for most chemicals. Precautionary minimization of exposure is recommended.
Regulatory consensus
4 regulatory and scientific bodies have classified AαC (2-Amino-9H-pyrido[2,3-b]indole). The classifications differ — that's the data.
| Agency | Year | Classification | Notes |
|---|---|---|---|
| EPA CTX / IARC | — | Group 2B - Possibly carcinogenic to humans | |
| EPA CTX / CalEPA | — | Known human carcinogen | |
| EPA CTX / Genetox | — | Genotoxicity: positive (Ames: positive, 4 positive / 0 negative reports) | |
| EPA CTX / Genetox | — | Genotoxicity: positive (Ames: positive, 4 positive / 0 negative reports) |
Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.
Where kids encounter aαc (2-amino-9h-pyrido[2,3-b]indole)
- Industrial Facilities — Manufacturing plants, Chemical storage areas, Waste treatment sites
- Occupational Environments — Factories, Warehouses, Transportation vehicles
Safer alternatives
Lower-risk approaches that achieve a similar outcome to AαC (2-Amino-9H-pyrido[2,3-b]indole):
-
Safer process chemistry; Green chemistry alternatives; Exposure controls
Trade-offs: Requires R&D investment to redesign synthesis routes; may reduce yield or throughput initially; long-term benefits include reduced waste treatment costs, regulatory compliance, and worker safety; 12 Principles of Green Chemistry framework available.Relative cost: 1.2-2×
Frequently asked questions
Is aαc (2-amino-9h-pyrido[2,3-b]indole) safe for kids?
Infants are more vulnerable to AαC (2-Amino-9H-pyrido[2,3-b]indole) than children or adults due to immature hepatic/renal clearance, higher intake-to-body-weight ratio, rapid organ development, and increased gastrointestinal absorption.
What products contain aαc (2-amino-9h-pyrido[2,3-b]indole)?
AαC (2-Amino-9H-pyrido[2,3-b]indole) appears in: Manufacturing plants (Industrial facilities); Chemical storage areas (Industrial facilities); Factories (Occupational environments); Warehouses (Occupational environments).
What should I do if my child is exposed to aαc (2-amino-9h-pyrido[2,3-b]indole)?
Minimize infant exposure through source control. For breastfeeding mothers: reduce maternal exposure. For formula-fed infants: use certified low-migration bottles and verified water sources. Consult pediatrician regarding any concerns.
Why do regulators disagree about aαc (2-amino-9h-pyrido[2,3-b]indole)?
AαC (2-Amino-9H-pyrido[2,3-b]indole) has been classified by 4 agencies including EPA CTX / IARC, EPA CTX / CalEPA, EPA CTX / Genetox, EPA CTX / Genetox, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.
See AαC (2-Amino-9H-pyrido[2,3-b]indole) in the baby app
Look up products containing aαc (2-amino-9h-pyrido[2,3-b]indole), compare to alternatives, and explore the full data record.
Open in baby View raw API dataSources (2)
- IARC Monographs Volume 56: Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins — IQ Group 2A; PhIP Group 2B, MeIQx Group 2B, MeIQ Group 2B, Glu-P-1 Group 2B, Glu-P-2 Group 2B, AαC Group 2B, Trp-P-2 Group 2B (1993) (1993) — regulatory
- EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific Opinion on the Risk for Human Health Related to the Presence of Heterocyclic Aromatic Amines (HAAs) in Food — PhIP, IQ, MeIQx, and related HCAs; Margin of Exposure approach; grilled and fried meat as primary exposure matrices (2021) (2021) — regulatory
Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →