Baby Safety / Compounds / 2-Acetyl-1-pyrroline

Is 2-Acetyl-1-pyrroline safe for babies and kids?

Low risk for kids

(Babies-specific data is limited; this page draws from human adult context.) 2-Acetyl-1-pyrroline poses low risk to adults under normal use conditions.

What is 2-acetyl-1-pyrroline?

The IUPAC name is 1-acetyl-1-pyrroline.

Also known as: 1-acetyl-1-pyrroline, 1-(3,4-Dihydro-2H-pyrrol-5-yl)ethanone, RefChem:84964, FEMA NO. 4249.

IUPAC name
1-acetyl-1-pyrroline
CAS number
85213-22-5
Molecular formula
C6H9NO
Molecular weight
111.14 g/mol
SMILES
CC(=O)C1=NCCC1
PubChem CID
522834

Risk for babies

Low risk

2-Acetyl-1-pyrroline poses low risk to adults under normal use conditions.

Regulatory consensus

2 regulatory and scientific bodies have classified 2-Acetyl-1-pyrroline. The classifications differ — that's the data.

AgencyYearClassificationNotes
EU——EU Cosmetics Regulation (EC) No 1223/2009 - extended allergen declaration requirement
IFRA——IFRA Standards on Fragrance Materials

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where kids encounter 2-acetyl-1-pyrroline

  • Perfume
  • Personal Care
  • Fragrance Mixtures

Safer alternatives

Lower-risk approaches that achieve a similar outcome to 2-Acetyl-1-pyrroline:

  • Fragrance-free product formulations
    Trade-offs: Eliminates allergen risk entirely; consumer acceptance varies (some associate scent with cleanliness/efficacy); growing market segment; regulatory advantage in EU (no IFRA compliance needed).
    Relative cost: Lower (ingredient elimination)
  • Essential oil-free synthetic fragrance blends with established safety profiles
    Trade-offs: Allows scent without specific natural allergens; synthetic molecules can be individually safety-tested; some synthetics have their own sensitization profiles; cost comparable to natural blends.
    Relative cost: Lower (ingredient elimination)
  • Encapsulated fragrance technologies (reduced dermal contact)
    Trade-offs: Reduces dermal contact by 60-90% via polymer shell release mechanism; higher formulation cost; may alter scent perception (delayed release); shell material itself requires safety assessment.
    Relative cost: 1.2-2×
  • Naturally-derived isolates at IFRA-compliant concentrations
    Trade-offs: Alternative fragrance ingredient; individual safety profile should be assessed per IFRA standards; sensitization potential varies by compound; patch testing recommended for sensitive individuals.
    Relative cost: 2-5× conventional

Frequently asked questions

No FAQ entries generated.

See 2-Acetyl-1-pyrroline in the baby app

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Sources (1)
  1. ATSDR Toxicological Profile — CAS 85213-22-5 — reference

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →